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Lee et al., 2004a,b

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Slowly increasing the dose of a GLP-1 medication allows the body time to adjust to the changes that are occurring, especially the slowing of gastric motility, says Currier, So the key to avoiding the nausea as much as possible is to take the titration phase slowly and allow the body time to acclimate appropriately. If someone increases the dose too quickly or overdoses, theyre more likely to experience severe nausea

The FDA designates curcumin as Generally Recognized As Safe (GRAS) for use as a food additive