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GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70,71,72

Inducible expression of the g-glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element

In certain embodiments, the viscosity enhancing agents or viscosity modulating agents described herein are also utilized as the gelling agent for the gel formulations presented herein

Of note the prolonged treatment with BSO did not substantially affect the weight of treated mice, suggesting limited undesired effects associated with this regimen

"Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme." Trends in Endocrinology & Metabolism

GSH levels in the liver are so central to detoxification capacity that liver function and glutathione status are directly linked