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In a clinical trial of people with obesity, tirzepatide caused an average weight loss of 15%21% in 72 weeks

Standard protocols use weekly injections

[1] For people with type 2 diabetes who are taking insulin or sulfonylureas alongside Wegovy, hypoglycaemia (low blood sugar) is another potential cause of fatigue that requires careful monitoring

1 (2017): 136143, 10.3945/ajcn.116.138594

Dosing these drugs without a clinician can land you in the hospital GLP-1 medications aren't a one-size-fits-all dose

In humans, GLP-1 alters palatable food intake and improves activity deficits in the insula, hypothalamus, and orbito-frontal cortex (OFC)