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Interestingly, the phospholipid metabolism is also possibly altered by riboflavin deficiency, because PLCA, an enzyme catalyzing the acylation of lysophosphatidic acid to form phosphatidic acid 35 , was up-regulated at the protein expression level in this study

It is possible that the transcription of the gene is periodic [60] and that the short-lived mRNA (minutes/hours [61]) may thus be absent most of the time, whereas the long-lived protein (days [62]) remains present and functional

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The key difference is receptor selectivity: MT-II is a non-selective melanocortin agonist binding across MC1R, MC3R, MC4R, and MC5R simultaneously producing tanning, appetite suppression, and sexual effects in parallel