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Jan 1992;55(1 Suppl):314s-317s

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The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta-analysis

It has been reported that essential hypertension is characterized by increased ET-1-mediated vasoconstrictor tone, which is an effect that seems to be dependent on decreased endothelial ET B -mediated NO production that is attributable to the impaired NO bioavailability

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It is also utilized in the treatment of various conditions such as Parkinson's disease, Alzheimer's disease, and cancer