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Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

Under carefully engineered pharmacologic conditions, it may become a complementary metabolic signal that helps transform incretin therapy from appetite suppression alone into a more comprehensive strategy targeting appetite, substrate oxidation, hepatic metabolism, and energy expenditure

This helps decrease overall calorie intake and promotes weight loss

WHY CRASH DIETS BACKFIRE When you slash calories and eliminate everything you enjoy, you might lose weight fast and then rebound harder

Real-world data indicate that the incidence of serious infections and thrombosis with tofacitinib is relatively low

Metabolic syndrome and dietary patterns: a systematic review and meta-analysis of observational studies