doi: 10.1016/s2542-5196(22)00090-0 150 BornmanMSAneck-HahnNHde JagerCWagenaarGMBouwmanHBarnhoornIEJet al
Deficiency Insufficient selenium intake may negatively affect the activity of several selenium-responsive enzymes, including glutathione peroxidases (specifically, GPx1 and GPx3), iodothyronine deiodinases, selenoprotein W, and methionine-R-sulfoxide reductase B1 (MsrB1)
In some cases, these side effects may result in discontinuation or dosage adjustments
If treatment is discontinued prematurely due to side effects, or if the dose remains suboptimal, the full therapeutic benefit may never be achieved
Both serum potassium concentrations and the platelet count need to be monitored carefully after parenteral administration of cyanocobalamin
Your healthcare provider will determine the appropriate dosage for you based on your current dosage and tolerance for side effects