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[18] [19] In males, prolonged HCG use may lead to gynecomastia due to increased aromatization of testosterone to estradiol

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73 Fewer studies have evaluated the risk of biliary disease, possibly due to impaired gallbladder emptying, 74 however, tirzepatide was shown to portend an increased risk (RR 1.97, 95% CI 1.143.42, I2 = 0.0%, p = 0.558)

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