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Hence, they hold great promise as biomarkers for early diagnosis, prognosis, and treatment approach of TNBC

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However, studies in mice showed that receptor blockade had about twice the impact on muscle growth compared to GDF8 blockade 9 , suggesting that there may be other negative regulators of muscle mass acting via these receptors

The concern that drives every prescribing label traces back to a rodent study in which rats and mice developed a rare thyroid tumor, and that signal has never been reproduced as a confirmed cause in people