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In laboratory models, Melanotan II is commonly used as a non-selective agonist of melanocortin receptors to study MC4R-related signaling pathways, owing to its strong receptor affinity

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As is the case with many low abundance DPP4 substrates, quantification of levels of intact vs DPP4-cleaved SDF-1 in vivo is challenging, due to the lack of sensitive assays for discriminating SDF-1 [167] from SDF-1 [367]

Gribble, F.M