In some embodiments, a concentration of the otoprotectant is at least or about 0.001 M, 0.005 M, 0.01 M, 0.05 M, 0.10 M, 0.5 M, 1 M, 5 M, 10 M, 20 M, 30 M, 40 M, 50 M, 60 M, 70 M, 80 M, 90 M, 100 M, 120 M, 140 M, 160 M, 180 M, 200 M, or more than 200 M
(3) PUFAs in Membranes: Polyunsaturated fatty acids (PUFAs) on cell membranes are oxidized and destroyed during ferroptosis, leading to loss of cell membrane integrity and cell death
Xin, Y., Wang, G., Han, W., Shen, Y., & Uyama, H
Free Radical Biology and Medicine 48, 13701381 (2010)
Weight loss starts slowly in the first 4 weeks of treatment, with changes in appetite and a feeling of fullness with fewer cravings
Potential Implications: The peptides efficacy in healing gastrointestinal fistulas and anastomoses suggests potential therapeutic applications in related conditions