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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Imeryz N, et al

"It also restored mobility to osteoarthritic mice and significantly reduced their pain." As a proof of principle that this might also work in humans, the researchers transferred human tissue into mice that were bred to not reject the tissue, and were able to show that human skeletal stem cells could be steered toward bone development but stopped at the cartilage stage

The compound works synergistically with berberine by activating complementary metabolic pathways, including AMPK signaling and mitochondrial biogenesis

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I can guarantee that every single one of those people is already struggling with (food) restriction