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This requires careful selection of populations who are most likely to benefit, such as older adults with low serum 25(OH)D levels, sedentary lifestyles, or mild cognitive impairment, as well as standardized intervention protocols that allow clearer interpretation

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MT-1 is a linear tridecapeptide closely matching the full -MSH sequence with Nle4/D-Phe7 modifications preferentially activating MC1R with limited central melanocortin receptor activity at research doses