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The denosumab reference products are Prolia and Xgeva, by Amgen

The tradeoffs are medical oversight, cost, the injection route for many of these medicines, and a distinctive side-effect profile led by gastrointestinal symptoms

Another difference is in approvals and added benefits

We suggest that renal function indicators should be monitored regularly after treatment

Missing Documentation for Long-Term Use: Update documentation for long-term therapy, and ensure that Z-codes are used to support continuous treatment