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The study found a reduction of 12% of LDL cholesterol after three months of supplementation with Pycnogenol significantly lower than the levels of the placebo group, which increased by 3% during the three months

In the regulation of innate immunity, the lack of the expression of NRF-2 entails a disturbance in the protective process of the host, as well as increased damage by hyperoxia, the increase of ROS, and inefficiency in the elimination and increase in the production of proinflammatory cytokines [28,29]

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