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A significant focus was on developing inhibitors of insulin-regulated aminopeptidase (IRAP), a protein identified as the AT4 receptor, with the goal of enhancing metabolic stability and BBB permeability

Though these agents do increase arousal threshold in OSA with a modest improvement OSA severity [86, 87], they may have the potential for neurological depression and worsening of hypoxemia associated with OSA at higher doses

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Indeed, research has shown that obese people also lack satiety-signalling GLP-1 - and so semaglutide was approved by the Food and Drug Administration (FDA) for weight management in 2021, with NICE (the UK's equivalent) following suit this year