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moderately to highly resistant to inactivation Worldwide infections number greater than 680 million recorded cases annually, with 200,000 deaths (from 2015 data) Is a very persistent virus in the environment (water and environmental surfaces) Has a low multiplicity of infection: It does not take a lot of viral particles to cause an infection (as low as 18 viral particles)* Infection is long lasting even after a patient has recovered (greater than 1 week with 100,000 to 1 x 10 12 viral particles per 1 g of stool from patient)

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