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Pyridoxine (B6) can reduce the effect of levodopa when levodopa is given without a peripheral decarboxylase inhibitor

Chemical Research in Chinese Universities, 39(3): 425433 Rodrguez-Chueca J, Carbajo J, Garca-Muoz P (2023)

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[8] In addition, drugs that affect blood cell production, such as certain chemotherapy agents or some HIV medications, may blunt the benefits of vitamin B or alter blood counts

However, you can prevent the B-12 deficiency by taking a proper diet and supplements.

However, when administered at much lower doses, LDN exhibits unique properties that can modulate the immune system, reduce inflammation, and increase the body's production of endorphins