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Such accumulation-related toxicity can involve multiple systems of the whole body, with clinical manifestations including chronic kidney disease, sensorineural deafness, chronic peripheral neuropathy, refractory anemia, and persistent cancer-related fatigue, which seriously impair the long-term quality of life and even affect the long-term survival outcomes of cancer survivors

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[PubMed: 40005999] Intra-articular Injection for Knee Pain (2021): A retrospective clinical study examined 16 patients who received intra-articular BPC-157 injections for knee pain

Defects in the FAH gene result in the accumulation of the upstream tyrosine metabolites, maleylacetoacetate and fumarylacetoacetate, as well as their metabolic by-products succinylacetone and succinylacetoacetate

The body transforms the food we eat into sugar and fat, which the mitochondria burns as fuel to produce energy

Biophysics Rep