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Cerutti 1994

The primary objective of most of the large, double-blind, randomized, placebo-controlled trials that have evaluated the cardiovascular effects of GLP-1 RAs in patients with type 2 diabetes focused on evaluating the presence of a MACE

34,35 Furthermore, the data for the different GLP-1 RAs in our study were pooled across different drugs and different routes of administration (oral or injection)

Food, other drinks, and even other tablets blunt how much drug gets absorbed

Third, and most consequentially for cagrilintide, every one of these measurements was made under acute or short-term dosing conditions that mirror amylins natural pulsatile release