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Consistent with the role of ghrelin signaling in regulating postprandial GLP-1 in lean mice, administration of the ghrelin receptor antagonist d-Lys3 abolished both the increased GLP-1 levels and the reduction in blood glucose levels observed in obese male Tmprss2 / mice following oral glucose challenge (Figure 6H)

So, they dont show results right away

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If the dose is increased too quickly, the intestines may not have enough time to adapt, leading to stronger and more uncomfortable side effects such as bloating, gas, nausea, or watery diarrhea

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