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Graphical Abstract Keywords Acetaminophen, Caspase-1, Drug-induced liver injury, Inflammasome, NOD-, LRR-, and pyrin domain-containing 3, NLRP3 Introduction Acetaminophen (APAP), commonly known as paracetamol, is a widely used over-the-counter medication renowned for its analgesic and antipyretic properties

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In preclinical studies, GW0742 has been shown to be protective at low doses but harmful at high concentrations

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