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He noted that the number would be even higher if it were an exclusively female sample and said it's "a signal worth investigating." The study found that approximately 44 percent of users reported at least one side effect, most commonly gastrointestinal issues, including 37 percent reporting nausea, which "shows that the method is picking up a real signal," according to Sharath Chandra Guntuku, the study's senior author

Journal of Emergency Medicine

Role of GLP-1R and GIPR expressing cells within the gut (incretin inflammation review)

User reports suggest effects may appear at lower doses than required for maximum weight loss

It is not advisable to split, crush, or chew tablets

In such cases, supplementation becomes necessary