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In July 2022, the EMA adopted a positive opinion, recommending the granting of marketing authorization for tirzepatide as a therapeutic agent for T2D (56)

After 17 years of GLP1RA use in humans there is no MTC signal Mice and rats (but not monkeys and humans), express GLP-1 receptors on their thyroid C cells and sustained GLP-1R activation in rodents produces thyroid C-cell hyperplasia

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GLP-1 (glucagon-like peptide-1) can cause a range of different side effects - thankful most are minor, shortlived and lessen as your body gets used to the treatment

Relative to SPF mice, GF mice have compromised microglial maturation and morphology, resulting in weaker responses to pathogen exposure (408)

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