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The use of experimental animals in this project conforms to the requirements of experimental animal welfare and ethics, and the procedures involving animals were in accordance with the ethical standards of Nanjing First Hospital (Protocol#: DWSY-1901438)

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During pregnancy, the size of the thyroid gland is increased by 10% in women residing in iodine-sufficient regions and increased by 20%-40% in those living in iodine-deficient regions (22)