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Instead of blocking specific immune pathways or depleting certain cell populations, tolerogenic strategies attempt to restore the fundamental regulatory mechanisms that prevent autoimmunity in the first place

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Earlier framings of "0.34 partial agonist at GCGR" or "0.4 softened agonist at GLP-1R" mistook potency ratios (EC50_LY EC50_native) for efficacy multipliers (E_max_LY E_max_native) and are retracted