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N-acetylcysteine can be given either through the IV or PO route

At high concentrations, QUE catalyzes the reduction of metal ions, generating ROS and causing oxidative damage to DNA and other cellular components (52)

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At the same time, iron-dependent lipoxygenase (LOX) catalyzes polyunsaturated fatty acids (PUFAs) to induce OS, which further alters the permeability of BBB (Figure 2)