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This understanding leads to clinical recommendations for integrated eye screening for AMD in all diabetic patients, as well as the potential for systemic diabetes drugs like metformin and SGLT2 inhibitors to offer a protective benefit against AMD in diabetic patients

Diabetes: from research to clinical practice: Volume 4 [Internet]

Incretin signaling at the crossroads of metabolism, inflammation, and tumorigenesis: implications for obesity patients

doi: 10.1186/s13722-024-00481-7, 41 FreetC

These constitute the neural pathway that connects the visceral sensory brainstem and the hypothalamic nucleus to participate in energy homeostasis

Because GCGR signaling has been linked to changes in hepatic energy turnover and fat oxidation, retatrutide offers a framework for examining how integrated endocrine signaling affects body composition readouts across tissues and model systems [1][5]