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The conditions that can lead to hyperbilirubinemia include: Dubin-Johnson syndrome Gilbert syndrome Crigler-Najjar syndrome Extra-hepatic biliary obstruction (blockage of bile flow outside the liver) Familial intra-hepatic cholestasis (blockages within the liver) Benign recurrent intrahepatic cholestasis (repeated non-dangerous blockages within the liver) Drug-induced hepatotoxicity (liver damage caused by drugs) Hemolysis (breakdown of red blood cells) Cholestasis of pregnancy (reduced or stopped bile flow during pregnancy) Viral hepatitis (liver inflammation caused by viruses) Autoimmune hepatitis (liver inflammation caused by the immune system attacking the liver) Wilson disease Hemochromatosis (too much iron in the body) Alpha-1-antitrypsin deficiency (shortage of a liver protein) Cirrhosis (scarring of the liver) Separating Rotor syndrome from other diseases causing high bilirubin levels is crucial

doi: 10.1016/j.jacc.2013.11.004 10 Del PratoSGallwitzBHolstJJMeierJJ

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doi:10.1016/j.sleep.2024.02.012