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Cardiol Rev

When storing peptides for months or even years, freezing is optimal in order to preserve the peptides stability

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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

SLC7A11 overexpression boosted cardiac GSH levels and reduced cardiac ferroptosis and injury in cardiomyopathy caused by loss of cardiac ferritin H (Fth MCK/MCK ) [76]