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[DOI] [PubMed] [Google Scholar] 105.Peier a, Kosinski j, Cox-york k, et al

If our bodies dont make enough of this protein, we can become deficient

See also Iron deficiency Patient Blood Management and surgery Blood product prescription The Australian Red Cross Blood Service anaemia and haemostasis overview Key Points Iron deficiency is the most common cause of anaemia in children Consider admission and discussion with local paediatrician or haematologist for children with red flag features Background Anaemia is defined as haemoglobin (Hb) less than the lower limit of the reference range for age Assessment History Lethargy Poor concentration Weakness Shortness of breath Ethnic background (can be helpful in guiding investigation for haemoglobinopathies and G6PD deficiency) Medication history: past and current, particularly those that may cause haemolysis in children with G6PD deficiency Dietary history: iron intake (with particular attention to iron-rich foods, breast feeding and cow milk intake), vitamin B12 intake, recent fava/broad bean ingestion (may precipitate haemolysis in children with G6PD deficiency) Family history: anaemia, jaundice, gallstones or splenomegaly Examination Poor growth Listlessness or fatigue Pallor Pale conjunctivae Tachycardia Cardiac murmur Signs of cardiac failure Shortness of breath Weakness Signs of haemolysis (jaundice, scleral icterus, splenomegaly and dark urine) Management Investigations FBC and film Reticulocyte count Ferritin Iron studies or serum iron should not be requested to diagnose iron deficiency

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Cobalamin status influences methylation and homocysteine metabolism View Source Biochemistry and physiology of vitamin B12 View Source Absorption and cellular uptake of vitamin B12 View Source Vitamin B12 and neural integrity: mechanistic research View Source

8.17, P = 0.033