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Methods We performed a retrospective chart review evaluating and characterizing glucagon-like peptide-1 receptor agonist exposures reported to a single poison center between 2006 and 2023
and provide antioxidant protection by scavenging ROS and upregulating Nrf2-dependent antioxidant enzymes (59, 60, 7981)
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Companion satellite-cell cultures, prepared at the same time, were immunostained at 30-h post-plating with D3 anti-desmin mAb and DAB (a chromogenic HRP-substrate that forms an insoluble brown reaction product) to determine the percentage of myogenic cells present 18 ,19 cultures with less than 95% DAB-positive cells (namely, less than 95% desmin-positive myogenic purity) were not used for experiments just to ensure the reliability of data specific to myogenic cells in the employed primary cell culture systems
In summary, GLP-1RAs offer a multifaceted therapeutic approach in AD by simultaneously targeting key pathological processes including amyloid accumulation and neuroinflammation
