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J Invest Dermatol 77:5964 Kopelent-Frank H, Mittlbck M (1996) Stability-indicating high-performance liquid chromatographic assay for the simultaneous determination of dixyrazine and chlorprothixene in intravenous admixtures

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From a central perspective, magnetic resonance spectroscopy studies have demonstrated that prefrontal cortex GABA concentration decreases by 1822% in depression patients, which was significantly and positively correlated to gut GABA-producing microbial abundance ( Probiotic intervention studies have provided direct evidence for the causal role of the GABA pathway in comorbidity

Additional risk factors include the use of various prescription and over-the-counter medications, otosclerosis, Menieres disease, vestibular schwannoma, head trauma, smoking, alcohol consumption, arthritis, obesity, and hypertension