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2.1.2 Molecular and cellular mechanisms underlying the pathogenesis of AD Amyloid plaques arise from the aggregation of A peptides, particularly A4 2 , which is harmful due to its tendency to form plaques and resist dissolving (Jarrett et al., 1993)
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Reverse transcription and real-time quantitative PCR (Q-PCR) Total RNA was isolated from frozen liver pieces using Tri-Reagent (Molecular Research Center, Inc.) according to manufacturers protocol
It then binds to intrinsic factor, a glycoprotein secreted by gastric parietal cells in the stomach lining
