doi: 10.1016/j.brainres.2011.06.063
The EMA has asked Novo Nordisk, which manufactures Ozempic, to add NAION to the list of side effects that can occur with very rare frequency. However, the US label for Ozempic does not contain this side effect
Many clinicians therefore prescribe Ozempic for weight loss for individuals with Type 2 diabetes who also have overweight or obesity
One study (from 1999) mentions the issue described above, but it is not a credible source for the following reasons: The study wasn't performed on normal human proteins or healthy, intact skin (instead, a blend of animal and human proteins, and the pH relationship issue developed only when a fatty acid byproduct was added to the mix)
It was this second property that drew their attention, as it was precisely the effect sought in type 2 diabetes patients, and they immediately got to work on exploring its potential as a therapeutic agent
The accelerated turnover has cleared years of accumulated congestion