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GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and regulatory T cells, resulting into the inhibition of inflammatory responses and the promotion of neuronal regeneration through interleukin-10 secretion

The patients who received the GLP-1 infusion had a significant improvement in left ventricular ejection fraction, VO2 max, and 6-minute walking distance

This study was conducted at the University of Pennsylvania School of Engineering and Applied Science

In other words, it is difficult to prove that these medications provide a direct benefit, rather than a secondary benefit from either weight loss or control of diabetes. He said more research is needed to determine if and how GLP-1 drugs can cause mood disturbances

doi: 10.9734/JCTI/2016/23786 39 KangYEJeongJOKimKHKiCSKimHJ