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Those who continued GLP-1 treatment for two or two-and-a-half years before discontinuing for the remainder of the study also gained significant risk reduction (7% and 15%, respectively)

elanclinic.ee 6AJMC (July 2026)

Since GLP-1 medications slow gastric emptying, higher-fat foods can worsen nausea or feelings of fullness, so lower-fat protein sources like bone broth may be better tolerated, says McGowan

Individual tolerance varies

Exendin-4, at least in Engs diabetic mice, caused blood glucose to drop to a normal level and stay there for hours, sometimes even for more than a day

Tirzepatide (Zepbound, 15 mg weekly), SURMOUNT-1, 72 weeks: mean weight loss approximately 22.5%