if semaglutide stops working 7 Reasons You Aren't Losing Weight on Weight Loss Drugs What keeps people on medications

So-called non-responders are people who lose less than 5% of their body weight after roughly six months of treatment on the highest tolerated dose

10.1002/art.21139 33 MessierS

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This was measured by melanin index reduction

Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brnneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brning JC (2014) Distinct roles for JNK and IKK activation in Agouti-related peptide neurons in the development of obesity and insulin resistance