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Set a tumor size of 2000mm 3 as the humanitarian endpoint based on the animal Experiment Humanitarian Endpoint Evaluation Guidelines(RBT173-2018, Certification and Accreditation Industry Standards of the Peoples Republic of China)

In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)

The four primary compounds each operate through distinct but sometimes overlapping molecular mechanisms, giving researchers flexibility in targeting specific pathway nodes

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Barbieri RL, Smith S, Ryan KJ