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Per FDA guidance, GLP-1-based medications are generally approved for adults with a BMI over 30, or over 27 with a qualifying health condition such as type 2 diabetes, high blood pressure, or high cholesterol

These outcomes reflect observed biomarker and pathway changes under controlled conditions and are not established therapeutic claims

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Annually after year 1: Annual B12 levels

Animal studies on obesity The most compelling data comes from studies in diet-induced obese mice