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This technique can be implemented in simpler instruments, such as triple-quadrupole mass spectrometers (those most commonly used for organic analysis in forensic toxicology, in diagnostic clinical chemistry and in metabolomic studies), or in state-of-the-art dedicated instruments, known as Guided-Ion Beam Mass Spectrometer(s) (GIBMS) [109]

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However, hypoglycemia risk increases significantly when combined with insulin or sulfonylureas, often requiring dose adjustments of these concomitant medications