In STEP-1, cholelithiasis (gallstones) occurred in 2.6% of the semaglutide group versus 1.2% on placebo, and cholecystitis occurred in 0.8% versus 0.4% [1]
In this Analysis, we searched for relevant literature on the effects of GLP-1RAs across a range of illnesses, gathering and describing the available pre-clinical and mechanistic (278 studies) and clinical (96 studies) evidence for cognitive disorders, substance-use disorders, psychotic disorders, mood and anxiety disorders, eating disorders, and others
With a focused trainer-to-client ratio, 17-point weekly tracking, registered dietitians designing every meal, and licensed psychologists supporting behavioral change, PFC delivers the kind of data-driven recovery many GLP-1 graduates need to build lasting strength and confidence
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References Elendu C, Amaechi DC, Elendu TC, Ashna M, Ross-Comptis J, Ansong SO et al (2023) Heart failure and diabetes: Understanding the bidirectional relationship
For the future, scientists are investigating how it could address metabolic disorders other than obesity, including non-alcoholic fatty liver disease and insulin resistance
