The lipoxygenase inhibitor zileuton is an oral specific inhibitor of 5-LOX for maintenance therapy in patients with asthma
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It is also approved to treat adult GH deficiency an uncommon condition that almost always develops in conjunction with major problems afflicting the hypothalamus, pituitary gland, or both
Neurologic complications are not always associated with megaloblastic anemia and are the only clinical symptom of vitamin B 12 deficiency in about 25% of cases (21)
Moreover, the optimal dose and formulation of melatonin for older adults require clarification sustained-release melatonin might better mimic the natural profile and sustain sleep through the night, for instance (Thanawala et al., 2024)
They can be worse at night, causing heavy sweating or night sweats