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Only a small subset of patients experienced minor tumor shrinkage, emphasizing the challenges posed by CSC heterogeneity and the pressing need for predictive biomarkers to guide future therapeutic stratification

The background medications used differed between the patient populations of included studies

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Small-molecule covalent modification of conserved cysteine leads to allosteric inhibition of the TEAD Yap protein-protein interaction

Ruiz-PozoVATamayo-TrujilloRCadena-UllauriSFrias-ToralEGuevara-RamrezPPaz-CruzEet al