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Step 3: Insert the needle through the rubber stopper at a 45-degree angle to minimize coring

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[DOI] [PMC free article] [PubMed] [Google Scholar] 287.Flieger J., Flieger W., Baj J., Maciejewski R

Additionally, mechanical effects from physical irritation including poorly fitting dentures, sharp teeth, or chronic repetitive injury have been proposed as cofactors, with case reports describing oral melanomas occurring at sites of chronic trauma and suggesting relationships with localized inflammation and chronic irritation that may stimulate melanocyte activation [8]