Deficiency in vitamin B12 can lead to problems with the digestive tract including heartburn, abdominal bloating, constipation, diarrhea, loss of appetite, and nausea and vomiting
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This results in the loss of an appreciable part of the cell death machinery, which determines the uniqueness of cell death pathways in mature erythrocytes
Our cells produce Glutathione (GSH) from three amino acids: cysteine, glutamic acid, and glycine
10.1007/s00592-023-02221-w 153 Nuez-MusaR
This is another reason why higher concentrations (10-20mg/mL) are preferred for higher doses, and why the reconstitution charts emphasize these concentrations for the escalation and maintenance phases