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Nonetheless, insurers in the commercial and public sectors have been reluctant to reimburse them as obesity medications
However, this enhanced efficacy came at the cost of lower tolerability
Sustainable weight loss is more likely with long-term lifestyle changes, such as healthy eating and regular exercise
Some states cover GLP-1 medications for diabetes but not weight loss, while others have implemented strict utilization management programs requiring extensive documentation before approval
According to That Clean Life, a company that offers customized diet plans for clients using GLP-1 medications, dietitians are essential in crafting nutrition strategies that align with these medications appetite-suppressing effects
In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]
