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Hypothalamic GLP-1R Knockdown and Rapamycin Benchmarking In the second cohort, 18-month-old mice received hypothalamic adeno-associated virus (AAV) encoding short hairpin ribonucleic acid (shRNA) to knock down GLP-1R or a scramble control, then exenatide or PBS for 13 weeks

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Bien que le corps puisse en produire, cette synthse dpend de plusieurs cofacteurs (vitamine C, vitamines B6 et B3, fer ) et peut tre insuffisante en cas dapports limits ou de besoins accrus (activit physique, rgime pauvre en produits animaux)