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Nasal delivery provides rapid absorption through the nasal mucosa, bypasses the GI tract, and requires no needles

Other common features include fragile, elastic skin with easy bruising, hypotonia (decreased muscle tone), kyphoscoliosis (kyphosis and scoliosis), and mild osteopenia (loss of bone density)

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This genomic architecture allows for the insertion of fragments exceeding 30 kb or deletion of multiple virulence genes without compromising its lytic replication cycle within tumor cells (8, 9)

48 weeks 6-8 x 10 mg vials Maintenance at 12 mg drives most of the total