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Published online May 2025:S0002916525002400 doi:10.1016/j.ajcnut.2025.04.023 Academy of Nutrition and Dietetics

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The continuing popularity of SUs as second-line drugs for diabetes can be explained not only by their long-established track record as insulin secretagogues but also by several endpoints, including efficacy, treatment adherence, decline in -cell function, tolerability over time, and affordability

A common mistake is making a decision too early without checking the details that affect suitability

Exceptions exist: GLP-1 agonists may have coverage with diabetes diagnosis or BMI over 30 with comorbidities

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